is a pharmacogenetic disease of skeletal muscle that may precipitate a potentially fatal sequence of metabolic responses in the presence of triggering anesthetics. The primary triggers for MH are - Inhalational Anesthetics and Succinylcholine.
Incidence estimated at 1:10,000 and 1: 150,000. Etiology involves the uncontrollable release of intramyoplasmic calcium (Ca2+) that results in sustained muscle contractures, which in return produces a hypermetabolic response. The hypermetabolic response manifests as hypercarbia, hyperthermia, tachycardia, and if not treated early, a mixed metabolic and respiratory acidosis, muscle rigidity, severe rhabdomyolysis, circulatory shock and possibly death.
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