Pediatric Anesthesia Digital Handbook
Department of Anesthesiology
Division of Pediatric Anesthesia
Tufts Medical Center
Boston, Massachusetts
United States of America

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​Perioperative Fluid Therapy in Infants and Children


There are 2 Main Components of Perioperative Fluid Therapy:

  1. Maintenance Fluid and Electrolyte Therapy
  2. Restoration or Replenishment Fluid Therapy

Maintenance Fluid Therapy

Represents the fluid and electrolyte requirements needed by the average individual with normal intracellular(ICF)and extracellular(ECF) fluid volumes OVER a 24-hr PERIOD.

Major Objectives of Maintenance Fluid Therapy include:
  • Provide WATER to meet physiologic needs/losses
  • Provide essential ELECTROLYTES (Na, K, Ca)
  • Provide minimum CALORIC needs

Infants have HIGHER fluid requirements:

  • Higher Rates of Metabolism and Growth
  • Greater Caloric Expenditure translates into Higher Fluid Requirements
  • Higher Insensible Fluid and Electrolyte losses due to a Greater Body Surface Area-to-Weight Ratio (almost
  • 3 times)
  • Lower Tubular Concentrating Ability, results in higher obligatory fluid loss.
  • Higher Respiratory Rates result in higher insensible losses

Restoration or Replenishment Fluid Therapy

Represents restoration of circulatory volume by expanding extracellular fluid. Replenishment fluid therapy aims to replace body fluids and electrolytes lost through bleeding, fluid shifts and/or other pathological processes. 

There are 2 major components of replenishment fluid therapy
  1. Replacement of deficits incurred during preoperative fasting, GI preps etc.
  2. Replacement of ongoing extracellular losses. These primarily include shed blood loss, third space loss and evaporative loss. Extent of these losses depend on severity of surgical and non-surgical tissue trauma

Choice of Intravenous Fluids

There are several factors which determine, the choice, volume and combination of intravenous fluids to be administered in the perioperative environment. These predominantly include the following:
  • Age of the patient 
  • Nutritional status and Mandatory Glucose Energy Requirements 
  • Level of cellular injury and trauma
  • Type and volume of ongoing fluid losses and/or fluid shifts

Until fairly recently (early - mid 1990s), hypotonic, dextrose containing fluids were primarily selected to restore circulating volume in  infants and children in the perioperative environment. However, as clinical research has established the risks and perils of hyponatremia and hyperglycemia, the recommendations have changed over the last decade. Clinicians have realized, that most of the perioperative losses consist of isotonic extracellular fluids like shed blood, and interstitial fluids which are rich in sodium and chloride. 

The following 3 tables summarize our recommendations for perioperative fluid therapy in neonates, infants, children and young adults:   


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Copyright © 2014. Aman Kalra, MD. Clinical Associate Professor of Anesthesiology, Department of Anesthesiology and Perioperative Medicine (Author, Illustrator and Web Designer)
800 Washington Street, Box 298, Tufts Medical Center, Boston, MA 02111. USA
LAST UPDATED February 26th, 2022